* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

body {
    font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, sans-serif;
    line-height: 1.6;
    color: #333;
    background-color: #f5f5f5;
}

#app {
    max-width: 1600px;
    margin: 0 auto;
    padding: 20px;
    display: flex;
    gap: 20px;
}

#app main {
    flex: 1;
    min-width: 0;
}

#organism_picker {
    flex-shrink: 0;
    width: 220px;
    padding: 16px;
    background-color: #f8f9fa;
    border-radius: 8px;
    font-size: 13px;
    max-height: 80vh;
    overflow-y: auto;
}

#organism_picker h2 {
    font-size: 14px;
    margin-bottom: 10px;
    color: #495057;
}

#organism_picker label {
    display: flex;
    align-items: center;
    cursor: pointer;
    padding: 4px 0;
    user-select: none;
}

#organism_picker input[type="checkbox"] {
    margin-right: 8px;
    cursor: pointer;
}


header h1 {
    font-size: 28px;
    font-weight: 600;
    color: #2c3e50;
}

main {
    background-color: #fff;
    padding: 30px;
    border-radius: 8px;
    box-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
}

#info {
    margin-bottom: 30px;
    font-size: 14px;
    color: #7f8c8d;
}

#visualization {
    min-height: 400px;
}

#graph-svg {
    width: 100%;
    min-height: 400px;
    background-color: #fff;
}

.placeholder {
    text-align: center;
    color: #95a5a6;
    padding: 60px 20px;
    font-size: 16px;
}

#controls {
    margin: 15px 0;
    padding: 10px;
    background-color: #f8f9fa;
    border-radius: 4px;
    font-size: 14px;
}

#controls label {
    display: flex;
    align-items: center;
    cursor: pointer;
    user-select: none;
}

#controls input[type="checkbox"] {
    margin-right: 8px;
    cursor: pointer;
}

#breadcrumb {
    margin-top: 5px;
    padding: 2px;
    background-color: #f8f9fa;
    border-radius: 4px;
    font-size: 14px;
    line-height: 1.5;
}

.breadcrumb-item {
    color: #007bff;
    transition: color 0.2s;
}

.breadcrumb-item:not(.active):hover {
    color: #0056b3;
    text-decoration: underline;
}

.breadcrumb-item.active {
    color: #6c757d;
    font-weight: 500;
}

.breadcrumb-separator {
    color: #6c757d;
}

@keyframes blink {
    0%, 100% { opacity: 1; }
    50% { opacity: 0.3; }
}

#message.loading {
    color: #ff00d0;
    animation: blink 1.5s ease-in-out infinite;
}

#message.error {
    color: #ff0000;
}

#search-info-box.error {
    color: #ff0000ab;
    font-size: smaller;
}

#search-box {
    margin-top: 5px;
}

.insert-example {
    font-size: small;
}

.insert-example .link-btn {
    background: none;
    border: none;
    padding: 0;
    font: inherit;
    color: #0066cc;
    cursor: pointer;
    text-decoration: underline;
}
.insert-example .link-btn:hover {
    color: #004499;
}